Genotype, blood type, zip code, gender, race, eye color, political partyĪn ordinal scale is one where the order matters but not the difference between values. You can code nominal variables with numbers if you want, but the order is arbitrary and any calculations, such as computing a mean, median, or standard deviation, would be meaningless.
Knowing the scale of measurement for a variable is an important aspect in choosing the right statistical analysis.Ī nominal scale describes a variable with categories that do not have a natural order or ranking. These are still widely used today as a way to describe the characteristics of a variable. We conclude that regulation of residual UBA1b translation is fundamental to the pathogenesis of VEXAS syndrome and contributes to disease prognosis.In the 1940s, Stanley Smith Stevens introduced four scales of measurement: nominal, ordinal, interval, and ratio. One mutation (c.121 A>T p.Met41Leu) caused severely reduced translation of UBA1b in a reporter assay, but coexpression with the second mutation (c.119 G>C p.Gly40Ala) rescued UBA1b levels to those of canonical mutations. Finally, we report a patient, clinically diagnosed with VEXAS syndrome, with 2 novel mutations in UBA1 occurring in cis on the same allele. In addition, we show that these 3 canonical VEXAS variants produce more UBA1b than any of the 6 other possible single-nucleotide variants within this codon. Using in vitro models and patient-derived cells, we demonstrate that p.Met41Val variant supports less UBA1b translation than either p.Met41Leu or p.Met41Thr, providing a molecular rationale for decreased survival. Multivariate analysis showed ear chondritis was associated with increased survival, whereas transfusion dependence and the p.Met41Val variant were independently associated with decreased survival. Patients with the p.Met41Val genotype were most likely to have an undifferentiated inflammatory syndrome. We analyzed 83 patients with somatic pathogenic variants in UBA1 at p.Met41 (p.Met41Leu/Thr/Val), the start codon for translation of the cytoplasmic isoform of UBA1 (UBA1b). We sought to determine independent predictors of survival in VEXAS and to understand the mechanistic basis for these factors. VEXAS syndrome is characterized by a high mortality rate and significant clinical heterogeneity. Somatic mutations in UBA1 cause vacuoles, E1 ubiquitin-activating enzyme, X-linked, autoinflammatory somatic (VEXAS) syndrome, an adult-onset inflammatory disease with an overlap of hematologic manifestations.
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